KMID : 1036020130020010009
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ÁöÁú.µ¿¸Æ°æÈÇÐȸÁö 2013 Volume.2 No. 1 p.9 ~ p.17
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Hypertension and Increased Left Ventricular End-diastolic Pressure Influence Arterial Stiffness
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Park Yae-Min
Chung Wook-Jin Lee Kyoung-Hoon Kang Woong-Chol Han Seung-Hwan Ahn Tae-Hoon Choi In-Suk Shin Mi-Seung Kim Bong-Roung
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Abstract
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Objective: There have been few studies regarding the relationship between arterial stiffness and left ventricular end-diastolic pressure (LVEDP). In the current study, we evaluated the relationship between the LVEDP and arterial stiffness in patients with hypertension (HTN).
Methods: Group I (n=34) included patients with a normal E/E¡¯ (¡Â8) without HTN, group II (n=31) included patients with an elevated E/E¡¯ (>8) without HTN, group III (n=20) included patients with a normal E/E¡¯ (¡Â8) with HTN, and group IV (n=49) included patients with an elevated E/E¡¯ (>8) with HTN. Aortic distensibility (AD) and the right brachial-ankle pulse wave velocity (baPWV) were measured.
Results: The mean age was 46.0¡¾11.3 years. The mean value of AD was significantly lower in the group III compared to the group I. The group IV showed significantly lower AD compared to the group II. The group III demonstrated higher baPWV compared to the group I (1422¡¾182 cm/sec vs. 1186¡¾178 cm/sec, p<0.01), and the group IV showed higher baPWV compared to the group II (1456¡¾228 vs. 1259¡¾238 cm/sec, p<0.01). However, AD and baPWV were not significantly different between the group I and II, and between the group III and IV. The E/E¡¯ ratio showed a weak negative correlation with AD and a weak positive correlation with baPWV.
Conclusion: Patients with hypertension showed a lower AD and a higher baPWV compared to those with normal blood pressure independent of the LVEDP. But the correlation between E/E¡¯ ratio and arterial stiffness suggests that a high LVEDP might not significantly influence arterial stiffness.
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KEYWORD
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Aortic distensibility, Pulse wave velocity, Hypertension
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